A Histone Deacetylase Regulates Addiction
نویسنده
چکیده
Epigenetic modification of chromatin has been proposed to translate environmental stimuli into persistent "cellular memories." Recent studies suggest that epigenetic pathways regulate long-term behavioral adaptation in the nervous system. In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine.
منابع مشابه
Regulated Shuttling of the Histone Deacetylase HDAC5 to the Nucleus May Put a Brake on Cocaine Addiction
The histone deacetylase HDAC5 has been shown to regulate behavioral adaptations to cocaine. In this issue of Neuron, Taniguchi et al. (2012) describe a cAMP-dependent signaling pathway that regulates nuclear accumulation of HDAC5, suggesting a mechanism to couple cocaine with changes in HDAC5 function.
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ورودعنوان ژورنال:
- Neuron
دوره 56 شماره
صفحات -
تاریخ انتشار 2007